课件：乳腺癌骨转移及双磷酸盐的应用.ppt

* 可手术乳腺癌口服固令辅助治疗能减少骨转移并改善生存率1069名I-III期乳腺癌患者在进行常规初治后随机分入两组,分别口服固令1600mg/d或安慰剂共两年，５年随诊表明口服固令可降低骨转移的发生，对II/III期患者这一效果尤其显著，骨转移的风险减少了41%。Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer [ISRCTTrevor Powles1 , Alexander Paterson2 , Eugene McCloskey3 , Phil Schein4 , Bobbi Scheffler5 , Alwynne Tidy6, Sue Ashley6 , Ian Smith6 , Lars Ottestad7 and John Kanis31Parkside Oncology, London, UK2Tom Baker Cancer Centre, Calgary, Alberta, Canada3WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield M