高效液相色谱法检测西药制品中甲醛残留的方法研究-食品安全质量.PDF

6 9 Vol. 6 No. 9 2015 9 Journal of Food Safety and Quality Sep. , 2015 董海峰, 沈上圯, 李琴梅, 刘伟丽, 魏晓晓, 段 艳, 高 峡, 张 梅* (, , , 100094) 摘 要: 目的 (HPLC)方法 2,4-2,4-, , -(60:40, V:V) 结果 2.38~14.28 mg/L , 92.21%, (RSD) 1.897%结论 , 关键词: ; ; Determination of formaldehyde residues in medicine by high performance liquid chromatography DONG Hai-Feng, SHEN Shang-Yi, LI Qin-Mei, LIU Wei-Li, WEI Xiao-Xiao, DUAN Yan, * GAO Xia, ZHANG Mei (Beijing Key Laboratory of Organic Materials Testing and Quality Evaluation , Beijing Engineering Research Center of Food Safety Analysis, Beijing Centre for Physical and Chemical Analysis, Beijing 100094, China) ABSTRACT: Objective To establish a method for determination of formaldehyde residues in medicine by high performance liquid chromatography (HPLC). Methods Formaldehyde in medicine reacted with 2,4-dinitrobenzenehydrazine to form 2,4-dinitrobenzenehydrazone, which was analyzed by high performance liquid chromatography with acetonitrile-water(60:40, V:V) as the mobile phase. Conditions for