四-三氟乙烷氧基空核酞菁的合成与光谱性质研究-中国现代应用药学.PDFVIP

·药物化学· 四-(三氟乙烷氧基)空核酞菁的合成与光谱性质研究 吴丽荣，黄丽英*(福建医科大学药学院，福州 350004) 摘要：目的 合成了一种新的化合物即四-(三氟乙烷氧基)空核酞菁(H PcF) ，并研究其光谱性质。方法 以4-硝基邻苯二 2 腈和三氟乙醇为起始原料，通过亲核取代反应合成 4-三氟乙烷氧基邻苯二腈；再利用醇锂法合成 H2PcF ，并通过熔点、 红外、质谱、元素分析等进行表征；同时研究其光谱性质( 包括紫外吸收光谱、荧光光谱) 。结果 H2PcF 的合成产率是 34.7% ，在可见光尤其是光动力治疗窗(600~800 nm)有较强的吸收，且具有很强的荧光性质和较高的荧光量子产率 (φ =0.29) 。结论 H PcF 具有良好的溶解性和光谱特性，在光电材料或光学治疗方面具有潜在的应用价值。 F 2 关键词：三氟乙烷氧基；空核酞菁；合成；荧光量子产率 中图分类号：R916.695 文献标志码：B 文章编号：1007-7693(2011)13-1327-04 Study on Synthesis and Spectral Properties of Tetra-trifluoroethoxy Substituted Metal-free Pathalocyanine * WU Lirong, HUANG Liying (Pharmacy College of Fujian Medical University, Fuzhou 350004, China) ABSTRACT: OBJECTIVE To synthesis a new compound of tetra-trifluoroethoxy substituted metal-free phthalocyaninate(H PcF) 2 and study its spectral properties. METHODS Firstly, 4-(trifluoroethoxy) phthalonitrile was synthesized by using 4-nitrophthalonitrile and 2, 2, 2-trifluoroethanol as starting materials by nucleophilic substitution. Then, H2PcF was synthesized based on the precursor of 4-(trifluoroethoxy) phthalonitrile and characterized by melting point, IR, MS and elemental analysis. Its UV spectrum and fluorescence spectrum were also studied. RESULTS The yield of H2PcF was 34.7%, it exhibited intense absorption in the visible region spectrum, mainly in the phototherapeutic window (600-800 nm) and strong fluorescence wih high fluorescence quantum yield(φ =0.29). CONCLUSION H PcF has shown potential application in photoelectric F 2 material or phototherapy filed due to its good solubility and spectral properties. KEY WORDS: trifluoro