微生物学通报材料表面特征对生物膜形成的影响及其应用.pdfVIP

微生物学通报 Jan. 20, 2018, 45(1): 155−165 Microbiology China /wswxtbcn tongbao@ DOI: 10.13344/j.microbiol.china.170182 专论与综述 材料表面特征对生物膜形成的影响及其应用 1 1 1 1* 2 熊富忠 赵小希 廖胤皓 温东辉 李琪琳 (1. 100871) (2. Department of Civil and Environmental Engineering, Rice University, Houston, TX 77005, USA) 摘 要：生物膜是微生物细胞粘附于材料表面的群体性生长方式。在实践应用中，有目的地调 控微生物在材料表面的成膜进程具有重要意义。本文概述了生物膜在材料表面的形成机制及其影 响因素，综述了材料表面的电荷特征、亲疏水性、形貌模式和功能性化学修饰等物化特性对细胞 粘附和生物膜形成的影响，并介绍了目前在不同实际应用场景中抑制成膜和促进成膜材料的研发 现状。 关键词：生物膜，细胞粘附，材料表面，物化特性，表面修饰 Effects of surface properties on biofilm formation and the related applications XIONG Fu-Zhong1 ZHAO Xiao-Xi 1 LIAO Yin-Hao 1 WEN Dong-Hui 1* LI Qi-Lin2 (1. College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China) (2. Department of Civil and Environmental Engineering, Rice University, Houston, TX 77005, USA) Abstract: Biofilm is a predominant lifestyle for microbes, in which microbial communities adhere to surfaces and are embedded in an extracellular matrix. Regulating the biofilm formation process on surfaces to meet practical demands is of great importance. Herein, we introduced the mechanism of biofilm formation on surfaces along with its key factors. The effects of surface properties, including surface charge, wettability, roughness, topographic patterns, and functional chemical modifications, on bacterial adhesion and biofilm formation were summarized in detail. Finally, we reviewed the research progress in material