非编码保守DNA序列形成与演化机制.pdf

生物技术通报 BIO TE CHN OLOG Y B ULLETIN 20 10 1 DNA 1 2 1 朱红霞 胡利宗 黄建新 1 2 ( , 453003; , 100101) : 作为一种系统进化足迹, 基因组非编码保守DNA序列受到 大关注由于非编码保守 DNA 序列很可能与转 录因子或特异蛋白质相互作用, 直接参与调控基因表达或稳定染色体结构等重要的生命活动因此, 它 有可能成为基因组 研究的下 一个新浪潮在总结对生物非编码保守DNA 序列的认识过程的基础上, 详细阐述了非编码保守DNA 序列形成与演 化的模型及其分子生物学机制, 进一步展望了非编码保守 DNA序列在生物学研究中的应用前景 : 生物 非编码保守 DNA序列 系统进化 M echanism of the Form ation and Evolution of Conserved N oncoding Sequences 1 2 1 Zhu H ongx ia Hu Lizong H uang Jianx in 1 2 ( X inx iang University, X inx iang 453003; Institute of Gen etics a nd D ev elopm en ta l B iology in CA S, B e i ing 100101) Abstrac:t Conser ed noncoding sequences w ith in genom es, known as a phylogenetic footprinting, ha e been extensi ely stud ied and concerned. It can regulate gene expression and stab le the specific chromosom e structure ia a direct or indirect interaction of tran scription factors or specific proteins. Consequently, conser ed noncod ing sequencesw ou ld becom e a next and new hotspot of genom e re searches. The bas ic process of know ing conser ed noncoding sequences w as summ arized and the m odels and molecu larm echanism of the form ation and e olution of conser ed noncod ing sequences w ere described in detail. Finally, the theoretical and app lied roles of con ser ed noncod ing sequences in b iological researches w ere further prospected. K ey w ords: B iology C onser ed noncoding sequences Phylogenetic rRNAtRNA