抗栓素缓释骨架片的制备工艺、质量标准和初步肠吸收情况研究-中药制剂学专业毕业论文.docxVIP

IV5．抗栓素初步肠吸收情况的实验研究 IV 5．抗栓素初步肠吸收情况的实验研究 采用离体实验中的外翻肠囊法对抗栓素的初步肠吸收情况进行研究，分别使用了大 鼠和家兔进行实验。结果：(1)抗栓素对大鼠小肠膜的透过吸收率最高约为8．32％，并 且在约1．25h时达到最大值，随着时间的延长，小肠外药液浓度反而回升。(2)抗栓素 对家兔小肠膜的_i彭撅收率最高约为17，51％，并且在约t．25h时达到最大值。随着时 间的延长，小肠外药液浓度反而回升。 主题词：抗栓索、缓释骨架片、肠吸收、制备工艺、质量标准、稳定性 VAbstract V Abstract Thrombus diseases concern with nlany subjects of elinic，i t do great harm to the health of human being，of which the death rate and cause disability date resulting from the thro【rIbosis of the heart and brain’s blood vessel are very high．Thrombosis involve artery thrombus and vein thrc)|】nbus，no matter which kind， the causes of it all include the injury of the endothelial tissue of blood vessel and the activation of cruor mechanisin． Kangshuansu(ISA)is a new component，which is a chemical complex of shikimene it has good solubility and stability，and it has a high bioavailability．It’s pharmacodynamics research show that it has good function of anti—thrombosis and can prevent the aggregate of blood platelet，especially it can effectively improve the damage caused by cerebral ischemia，and it has no influence to the normal cruor mechanism of organism．Therefore，Kangshuansu(ISA)as a new drug used in the treatment of thrombosis has a good prospect of application． Based on the existing research of Kangshuansu(ISA)，mare research about it including it’s basic properties、pharmaceutical technology、quality standard、 stability and preliminary absorption research of smali intestine are studied， which laid the groundwork for the further clinic research and application． 1．The complementary research about basic properties of Kangshuansu(ISA) (1)Research about Kangshuansu(ISA)’s stability at different pH．Result It is instable in p}{l～4，and in company with the decline of Ot it’s stability rundown．And it is stable in 8 hours when the pH is above 5 (2)measuring Kangshuansu(ISA)’s oil／water partition coefficient．Result It’s oil／water partition coefficient is downtrend in pH5．0～lO．0 at room temperature，and temperature，