毛细胞白血病——附1例报告-内科血液学专业毕业论文.docxVIP

毛细胞白血病 毛细胞白血病 ——附一例报告 摘 要 目的毛细胞白血病是一种以慢性淋巴样细胞增殖紊乱为特征的血液系统 恶性肿瘤，WHO(2000)分型将其归为非霍奇金淋巴瘤(N壬IL)成熟B细 胞肿瘤的一个亚型，临床上较为罕见，近年全球发病呈上升趋势。报告一 例毛细胞自血病，以提高对毛细胞自血病的认识，探讨其诊断、治疗及预 后。 方法对本例毛细胞白血病临床特点进行描述性研究，并同时进行相关文献 复习。 结果本例毛细胞白血病经正确诊断、治疗处于持续缓解状态，预后良好。 通过文献复习明确了毛细胞白血病的l临床特征，毛细胞白血病的诊断需与 其它类似少见血液系统肿瘤相鉴别，必要时需借助电镜等检查，治疗方法 的选择、 合适治疗干预时机的选择及定期复查、随访是改善预后的关键。 结论毛细胞白血病是缓慢进展的血液系统恶性肿瘤，对于相对静止稳定的 无症状患者，谨慎的等待与观察是较为适宜的。嘌呤核苷酸类似物具有较 好的治疗效果，故对需要治疗的进展型毛细胞白血病患者应作为首选，其 次为重组干扰素，重组干扰素治疗失败者可以选择嘌呤核苷酸类似物。多 次复发者试用免疫治疗或联合治疗方法。 关键词白血病，毛细胞，诊断，治疗，预后 山西医科大学颈士学位论文Hairy 山西医科大学颈士学位论文 Hairy cell leukemia——One case report and literature review Abstract objective：Hairy cell leukemia(HCL)is rare，chronic B—lymphocyte malignancy characteristically unresponsive to traditional chemotherapy．In WHO(2000)classification．it is subtype of NHL．The incidence rate is}ligher and hi翻aer in recent years．One was reported for promoting the understanding ofhairy cell leukemia． Materials and methods：The detailed clinieal featnres of the were analysed,and the related literature was reviewed． Resultes：The patient was gaven right treatment and has achieved complete remisson．Long follow-up indicates that he is still in the state of complete remisson which predicts the good prognosis．By learning the literature，the character of HCL is determined．The diagnosis of hairy cell leukemia isnt very difficult,but must be differentiated with other hematological malignancies such chronic lymphocytic leukemia．splenic lymphoma with villous lymphocytes and on．To determine the fight treatment hour and check important． Follow—up is indispensable to improve the prognosis． Conclusions：The clinical of its development is slow．Watchful wating is appropriate for asymptomatic patients．Patients who develop significant neutropenia(absolute neutmphil count1×10)anemia(hemoglobin coneentration10．og／1) in the of their disease should be considered．Patients with symptomatic splenomegaly，constitutional symptoms such fever night sweats due to HCL，or repeated infections may ben