慢性粒细胞白血病骨髓MRI表现及临床应用分析-影像医学与核医学专业毕业论文.docxVIP

山明医科大学 山明医科大学 硕j：论文 慢性粒细胞白血病骨髓MRI表现 及临床应用分析 摘 要 酱的 探讨慢性粒缅簏白趣病(chronic myeloid leukemia， CML)露髓Mill表现旋其临床巍聚价值。 方法 搜集经细胞形态学、免疫分型及遗传学(MIC分型) 综合分孝露确诊的成人CML41铡，其中初诊慢性期患者12例，治 疗后病情稳定于慢性期者18例，维持一定时间慢性期尉，病情 发展到加速期者3例，发生急性变者8例。所有患者均行骨盆 及股骨中上段MRI检查，选取20例年龄瓯配的健康志愿者作为 对照组。 结果 初诊慢性期及进展到加速和急变期的患者SE序列 T。wI表现为髂骨殷股骨弥漫性低信号或仅在股骨头、大转子处 残留斑片状离信号。治疗盾维持在慢性期的患者SE序列TtWI 表现为髅骨弥漫低信号或以低信号为主夹杂点片状高信号，股 骨主要表现为高低混杂信号。初诊慢性期组与治疗后患者组、 治疗后患者组与加速急变缌MRI表现差晃具有显著性意义(两 组鼍王均秩次之差分别为20。167，18。689，P傻均0。01；翅渗 慢性期组与加速急变期组毙较蕤募无显著性(嚣缀平均秩次之 差为1．477，P0．05)。 1 山西医科人学 山西医科人学 硕士论文 结论 CML患者骨髓MRI能反映其病程的演变，MRI与临 床特点结合，有助于CML的诊断分期，并且对监测病情发展、 提示加速和急变有重要价值。 关键词 骨髓 磁共振成像 白血病 慢性 山两医科大学 山两医科大学 硕：卜论文 MR imaging of bone marrow in patients with chronic myeloid leukemia and its clinical value ABSTRACT objective To describe the MR imaging characteristics of chronic myeloid leukemia and to assess its clinical value of diagnosing and staging． Methods M鼯of pelvis and femur were performed on 4 1 adult patients diagnosed as chronic myeloid leukemia based Otl morphology,妇nf魏H魏ophenolype and cytogenetic analysis。 Disease status was classified as newly diagnosed chronic phase in 1 2 cases，steady chronic status in 1 8 cases accepted effective treatment，accelerated phase in 3 cases and blastic phase in 8 cases after a long chronic phase．20 age．matched healthy volunteers were selected as controls Results MR imaging of patients newly diagnosed chronic phase and transformation into accelerated or blastic phases on TlWI spin echo showed either diffusal and unifbrm low signal intensity in ilium and femur or only punctual or sheet highy signal intensity was seen in femoral head and greater trochanter。The distribution of the patterns had no statistical significance(PO．05)．The 1 8 cases in steady chronic statu8 w}10 3 山西医科人学 山西医科人学