慢性间歇性低压低氧对雌性Zucker大鼠 心脏保护作用的研究-生理学专业毕业论文.docxVIP

万方数据 万方数据 目 录 中文摘要····································································································1 英文摘要····································································································5 英文缩写··································································································10 研究论文 慢性间歇性低压低氧对雌性 Zucker 大鼠心脏保护作用的 研究 前言··································································································11 材料与方法······················································································13 结果··································································································17 附图··································································································21 讨论··································································································40 结论··································································································43 参考文献··························································································44 综述 不同形式的间歇性低氧对代谢综合征心脏的影响··················49 致谢··········································································································64 个人简历··································································································65 中 中 文 摘 要 PAGE 10万方数据 PAGE 10 万方数据 慢性间歇性低压低氧对雌性 Zucker 大鼠心脏保护作用的研究 摘 要 目的：随着人们生活水平的提高和饮食结构的改变，肥胖变得越来越 常见，严重影响了人类生活质量和寿命。据统计，肥胖在女性群体中发生 率明显高于男性。肥胖常导致代谢综合征（metabolic syndrome，MS），伴 有蛋白质、脂肪、碳水化合物等物质发生代谢紊乱，表现为包括腹型肥胖、 胰岛素抵抗、糖代谢异常、高血压及脂代谢异常等。代谢综合征可导致多 器官损害，带来一系列疾病，如：痴呆、痛风、脂肪肝、血小板活化、血 粘度增加、糖尿病、动脉狭窄、冠心病等。肥胖、高血压、脂代谢紊乱、 高血糖、胰岛素抵抗等因素单独或合并存在时，均可引起并加重心脏结构 和功能的异常。肥胖 Zucker 大鼠（OZR）是 5 号染色体上 leprfa 常染色体 隐性遗传突变，Gln 的错义突变 Pro 残基的在瘦素受体 269 的位点，表现 为肥胖及代谢综合征，被认为是一个人类肥胖和代谢综合征的理想模型。 慢性间歇性低压低氧(chronic intermittent hypobaric hypoxia, CIHH)是 指一定时间暴露于低压低氧环境，而其余时间处于常压常氧环境。已有大 量研究表明，CIHH 类似缺血预适应，具有明显的心脏保护作用，表现为 增强心肌对缺血/再灌注(ischemia/reperfusion, I/R)损伤的耐受性。我们近 期的研究发现，CI