慢性不可预知性应激对大鼠前额皮质DRD2受体表达的影响及其可能机制-药理学专业毕业论文.docxVIP

安徽医 安徽医科大学硕士学位论文 5 结果 ············································································· 22 5.1 CUMS 对大鼠体重变化的影响 22 5.2 CUMS 对大鼠糖水消耗、悬尾不动时间的影响···················· ·················································································· 22 5.3 CUMS 对大鼠血清及前额皮质中 cAMP 水平的影响错误 ! 未定 义书签。 5.4 CUMS 对大鼠前额皮质中 DRD2 表达的影响错误!未定义书签。 5.5 CUMS 对大鼠前额皮质中 PKA 表达的影响 错误!未定义书签。 5.6 CUMS 对大鼠前额皮质中 CREB/p-CREB 表达的影响 23 5.7 CUMS 对大鼠前额皮质中 Gαs, Gαi 表达的影响 27 6 讨论 ············································································· 28 6.1 CUMS 模型大鼠的建立及行为学指标的检测 28 6.2CUMS 可 能 通 过 调 节 大 鼠 前 额 皮 质 DRD2-Gαs/Gαi cAMP-PKA-CREB/p-CREB 信号转导通路导致行为学的变化 30 7 结论 ············································································· 32 参考文献 ·········································································· 33 附录 ················································································ 34 致谢 ················································································ 40 综述：度洛西汀与帕罗西汀治疗成人抑郁症临床疗效及安全性的 Meta 分析 ················································································ 41 PAGE PAGE 1 英文缩略词对照(Abbreviation) 英文缩写 5-HT 英文全名 5-hydroxytryptamine(serotonin) 中文全名 5-羟色胺 AC adenylate cyclase 腺苷酸环化酶 ATP adenosine Triphosphate 三磷酸腺苷 BDNF brain-derived neurotrophic factor 脑源性神经营养因子 cAMP cyclic adenosine monophosphate 环磷酸腺苷 CMC-Na sodium carboxymethylcellulose 羧甲基纤维素钠 CREB cAMP response element binding protein cAMP 反应元件结合蛋 白 慢性不可预见性的应激 CUMS chronic unpredictable mild stress 抑郁模型 d day 天 DA dopamine 多巴胺 DRD2 dopamine 2 receptor 多巴胺受体 2 GABA γ-aminobutyric acid γ-氨基丁酸 Glu glutamic acid 谷氨酸 HPAA hypothalamic pituitary adrenal axis 下丘脑-垂体-肾上腺皮 质轴 IL interleukin 白细胞介素 ig intragstric administration 灌胃给药 NE norepinephrine 去甲肾上腺素 PFC prefrontal cortex 前额皮质 PKA protein kinase A 蛋白激酶 A RIA radioimmunoassay 放射性免疫测定法 SNRIs selective norepine