慢性阻塞性肺疾病急性加重期异质性的临床初步分析-内科学(呼吸系病)专业毕业论文.docxVIP

摘要 摘要 PAGE PAGE IV ABSTRACT Objective: By detecting the levels of serum IL-6, CRP, fibrinogen,combined with its clinical characteristics,visual assessment of emphysema and other clinical data in patients with acute exacerbation of chronic obstructive pulmonary disease,to explore the heterogeneity of acute exacerbation of chronic obstructive pulmonary disease(AECOPD), and to provide the basis for the diagnosis and treatment of AECOPD. Methods: Selecting 69 eligible patients with AECOPD from Dept of Pulmonology,the Second Affiliated Hospital of Nanchang University ,during August 2014 and February 2014,including 53 males and 16 females;divided into bacterial infection group ,viral infection group and pauci-inflammatory group referencing Bafadhel classification.18 physical examination person in the same period in the Second Affiliated Hospital of Nanchang University,including 14 males and 4 females All hospitalized patients completed the clinical data collected at the day of admission, serum IL-6 levels were determined by enzyme-linked immunosorbent assay (EILSA), parallel chest CT, arterial blood gas analysis, blood, CRP, fibrinogen, the groups were compared between groups, and the correlation analysis conducted in patients with the detection of indicators. Results: AECOPD patients with the serum CRP levels significantly are higher than the control group, which was higher than the bacterial virus group, with less inflammation group, the differences were statistically significant (P 0.05); In each group of AECOPD patients with elevated fibrinogen levels compared with the control group, the difference was statistically significant (P 0.05), no significant difference (P fibrinogen concentration difference between the groups of patients AECOPD 0.05); PAGE PAGE V Patients in each group AECOPD IL-6 levels significantly higher than the control group, the difference was statistically significant (P 0.05), in which groups of bacteria higher than viral group and less infla