课件：利鲁唑组比值治疗前后比较.ppt

THANK YOU SUCCESS * * 可编辑 Dextromethorphane DM) + Quinidine (Q)85 Neurodex? USA N=140 3 arms: DM, Q and DMQ Centerfor Neurologic Study Lability Score DM is antagonist of Glutamate receptor (NMDA); Quinidine inhibits DM metabolism, D/Q combination effective in Symptomatic treatment of pseudobulbar affect Publication pending increasing availability Dextromethorphan（右美沙芬），动物实验用有效，不能阻止疾病发展。 对假性延髓麻痹作用尚不明。 Vitamin E26? N=268 Norris limb scale antioxidant No significant difference France 500mg BID plus riluzole follow-up 12 months Vitamin E27-- N=160 Death or tracheostomy antioxidant No significant Difference between groups, Europe 5000mg QD plus riluzole Well tolerated follow-up 18 months Selegiline25 N=133 Appel total score Antioxidant Negative, Exclusion MAO-B ALS5yrs Eldepryl? inhibitor, USA Acetylcysteine24 N-=110 Death, Antioxidant negative The Netherlands 50mg/kg/day sc tracheostomy Follow-up 12 months CoenzymeQ10105 N=185 ALSFRSr Mitochondrial cofactor, antioxidant Includes FVC60% and Symptom onset 5 years USA Phase Ⅱ 9 months study period Verapamil104 N=72 MVIC and pulmonary Antioxidant negative Treatment function effect com