麻杏芎葶合剂加泼尼松治疗肺间质纤维化的临床疗效观察-中医内科专业毕业论文.docx

中文摘要 本文通过宣肺平喘，豁痰逐瘀法对 27 例肺间质纤维化患者的临床疗效观察，分析麻 杏芎葶合剂加泼尼松对于肺间质纤维化患者泼尼松减量时间、病情的影响，评价其疗效。 临床观察部分： （1）目的：评价麻杏芎葶合剂加泼尼松治疗（痰瘀互阻型）肺间质纤维化的有效性、安 全性。 （2）方法：纳入符合标准的 PF 患者 27 例，根据病情程度分别给予不同剂量的泼尼松加 中药麻杏芎葶合剂，每日 2 次口服；泼尼松的用法参照 2002 年中华医学会呼吸病学分会 《特发性肺（间质）纤维化诊断和治疗指南（草案）》治疗 3 个月后评价麻杏芎葶合剂加 泼尼松治疗肺间质纤维化的有效性、安全性。 （3）结果：治疗前后患者的中医症状积分统计结果显示有显著性差异（P0.05）。治疗 后患者的肺功能（TLC、VC、DLco）、胸部高分辨 CT、指氧饱和度均有不同程度的改善。 麻杏芎葶合剂加泼尼松，泼尼松开始减量的时间与指南中推荐的 4 周相比缩短了 12 天， 泼尼松剂量减半的时间与 4 周相比提前了 4 天，泼尼松减量为 10mg 的时间较指南中 3 个 月相比提前了 53 天。 理论探讨部分：麻杏芎葶合剂和泼尼松治疗（痰瘀互阻型）肺间质纤维化的增效减副的 作用机制。 关键词：肺间质纤维化；麻杏芎葶合剂加泼尼松治疗；宣肺平喘、豁痰逐瘀法 Abstract This paper research Xuanfei asthma, Phlegm and removing stasis in 27 cases of pulmonary fibrosis in patients with clinical observation, analysis Ma Xing Xiong Ting mixture with prednisone for pulmonary fibrosis patients hormone reduction time, the disease and assess their efficacy. Clinical Observation: (1) Objective: To evaluate Ma Xing Xiong Ting mixture with prednisone (phlegm and blood stasis type) the effectiveness of pulmonary interstitial fibrosis, safety. Methods: A standard PF, 27 patients were treated according to severity of different doses of prednisone plus traditional Chinese medicine Ma Xing Xiong Ting mixture, 2 times per day orally; prednisone usage of the light in 2002 Chinese Medical Association Credits will respiratory disease, idiopathic pulmonary (interstitial) fibrosis in the diagnosis and treatment guidelines (draft) Evaluation of 3 months after treatment Ma Xing Xiong Ting mixture plus prednisone in the treatment of pulmonary fibrosis efficacy, safety . Results: After treatment, symptom scores of patients with Chinese statistics showed there were significant differences (P lt;0.05). After treatment, lung function (TLC, VC, DLco), high resolution chest CT, mean oxygen saturation had different degrees of improvement. Ma Xing Xiong Ting mixture with prednisone, pred