黄竹清脑颗粒对痰热腑实证脑出血大鼠血浆中CCK的影响-中医内科学专业毕业论文.docxVIP

脑颗粒有类似血浆 CCK 拮抗兴奋性氨基酸神经毒性作用，从而起到减轻颅内 血肿及脑水肿、脑缺血后的再灌注损伤，进而保护脑细胞的作用。 关键词： 黄竹清脑颗粒；脑出血；痰热腑实证；CCK; Huang zhu Qi ng Nao Par t i cl es( HZQNP) pai r s of phl egm- heat i nt er nal or gans r eal cer ebr al hemorr hage i n r at s t he eff ect s of pl asma CCK ABSTRACT Purpors: Discusses Huang Zhu Qing Nao Particles to the phlegm hot internal organs reality cerebral hemorrhage big mouse blood plasma in the CCK influence. Methods: Random SD 60 adult male rats were grouped particles can be divided into Huang Zhuqing brain dose group (10), Huang Zhuqing brain particles dose group (10), Huang Zhuqing brain was smaller dose group (10), phlegm Fu empirical model group (10), Qingkailing group (10), blank control group (10). In addition to the blank group, the rest of the group of reference [1] Copy phlegm-heat internal organs solid-type model, with 10% autologous feces 1ml/100g gavage, 1 / d, continuous 3d, the first 3 days are in three-dimensional positioning system used under Ⅶ - heparin mixture injected into the establishment of phlegm-heat internal organs real brain cerebral hemorrhage model. After a successful modeling gavage, Japan time, 3 consecutive days. The femoral vein to take blood and then placed in pre-cooled test tube aprotinin (500KIU/ml) 50ul, instantly 4 ℃ centrifugation (4000r/min) 10min centrifugation take plasma CCK levels measured . Result: (1) phlegm-heat internal organs empirical modeling after intracerebral hemorrhage in rats, animal feces are dry, irritability, nasal secretions and more throats of phlegm Ming Positive symptoms such as phlegm-heat internal organs and nervous system symptoms of cerebral hemorrhage, and the model group Compared with the control group, plasma CCK was significantly higher (P 0.05), prompted modeling success. (2) HZQNP can significantly reduce the phlegm-heat internal organ