不同子宫动脉灌注化疗方案加栓塞术治疗异位妊娠临床疗效的随机双盲对照研究.doc

第四军医大学硕士学位论文 we designed this clinical trial, the purpose is to evaluate the efficacy and safety of two kinds of UACE in the treatment of EP. Objective: To evaluate the efficacy and safety of two kinds of UACE in the treatment of EP. Methods: A single center, randomized, double-blind, controlled clinical trial was carried out. A total of 50 cases of EP patients were randomly divided into the treatment group (perfusion chemotherapy with MTX and 5-FU and embolization) or the control group(perfusion chemotherapy with MTX and embolization) and were treated with two kinds uterine artery perfusion chemotherapy and embolization. The primary efficacy endpoints were the serum β-HCG value , the clinical healing time, the tubal patency rate after UACE. The adverse events were recorded. Analysis of covariance, analysis of variance for repeated measurement data, t test, and χ2 test were used for statistical analysis. Results: The differences between the two groups of serum β-HCG values on the main effect of treatment method and time interaction were not statistically significant. The difference of time effect of the two group was statistically significant.There was no significant difference between control group (26.74±5.57 d) and treatment group (28.57±5.08 d) on the clinical healing time. There was no significant difference between control group (78.9%) and treatment group (76.2%) on the tubal patency rate. Two groups of postoperative adverse events were mild，there was significant difference between control group (26.1%) and treatment group (58.3%) on the incidence of adverse events. Conclusion: Two kinds of intervention methods have the same clinical curative effect, however, the incidence of adverse events of control group is lower than treatment group. We recommend using a signal MTX perfusion chemotherapy and embolization in the treatment of ectopic pregnancy. Key words：Ectopic pregnancy;Treatment；Uterine artery chemotherapy and embolization; Methotrexate; 5-Fluorouracil -