凉血止血祛瘀法对糖尿病大鼠作用机理的实验研究-中医基础理论专业论文.docxVIP

黑龙江中医药大学硕士学位论文英文缩略语表 黑龙江中医药大学硕士学位论文 英文缩略语表 DM Diabetes Mellltus 糖尿病 IDDM Insulin-Dependent Diabetes Meliitus 胰岛素依赖型糖尿病 NIDDM Non·Insulin—Dependent Diabetes Meilitus 非胰岛素依赖型糖尿病 STZ Streptazoeln 链脲佐菌素 C．P C-Peptide C肽，c一肽 Ins Insuliu 胰岛素 FBG Fasting Blond Glusose 空腹血糖 RIA RadIDl哪mUnDa88ay 放射免疫分析(测定) IRI ImmanoreacUve insulin 免疫反应性胰岛素 PI 胰岛素原，胰岛素前体 摘 摘 要 本课题针对糖尿病的发病特点，提出凉血止血祛瘀法。探讨了 该法的理论基础，确立了凉血止血祛瘀法治疗糖尿病的有效方剂“济 津汤”，对止血法治疗糖尿病进行了深入研究，扩展了止血法的应用 范围。应用由链脲佐菌素造成的实验性糖尿病大鼠动物模型，以 FBG、Ins、C．P以及血液流变学为指标，从病理组织形态学角度对 该法的治疗效果进行研究，阐明了凉血止血祛瘀法在糖尿病治疗上 的有效性。实验结果表明：凉血止血祛瘀法可以有效降低糖尿病大 鼠的FBG，其作用机理可能是通过改善胰岛B细胞的分泌功能实现 的。凉血止血祛瘀法可以有效地缓解糖尿病状态下的微循环障碍， 提示该法能够对微循环改变所导致的糖尿病并发症进行干预。凉血 止血祛瘀法对糖尿病大鼠的胰腺、心脏、‘肾脏的病理改变均有不同 程度的治疗作用，说明该法能够缓解由链脲佐菌素所导致的胰岛≯ 细胞损伤，并对糖尿病心、肾并发症的产生有一定治疗作用。实验 结果在证实该法治疗糖尿病有效性的同时，为扩展凉血止血祛瘀洼 的应用范围提供了客观依据。研究结果说明，精微耗散这一病理基 础贯穿糖尿病始终，凉血止血祛瘀法是阻止糖尿病状态下体内精微 损耗和散失的有效治法，对糖尿病劳发症也有一定的疗效，值得深 入研究。 关键词：糖尿病 实验研究 凉血止血祛瘀法 济津汤 黑龙江中医药大学硕士学位论文AB 黑龙江中医药大学硕士学位论文 AB STRACT The evidence from the experiments described in the article aimed at the pathogeny of Diabetes Mellitus(DM)and advances the therapv of cool blood and block blood and break stasis．The base of the therapy in—theory and the establishment of effective prescription named Jijintang，which expresses the therapy of cool blood and block blood and break stasis，are studied and discussed．A using the therapy of block blood DM is studied intensively，thereby advancing its range for application．The test model used diabetes mellitus rats，which were treated by STZ．The hemorrheological indexes were observed and the FBG；the Ins and C。P were examined and analyzed by Microscopic to observe microcosmic pathological changes。The experiments showed that the therapy was effective against DM．The study’S conclusion is that Ca)The therapY of c001 blood and block blood and break stasis reduce the DM in rats， FBG and that the effect may be caused by the improvement of B-cell the pancreas；(b)the therapy improve the microcirculation effectively，thus reflecting that the therapy