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医学综述范文 -胰岛β细胞转录因子FoxO1的研究进展 信息来源： 发布日期：1/14/2012 11:20:05 AM 郑舒静△( 综述) ,陈诺琦※( 审校)( 福建医科大学附属漳州市医院内分泌科, 福建 漳州 363000)中图分类号: R587. 1 文献标识码: A 文章编号: 1006-2084( 2011) 01-0047-03 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 医学综述范文摘要: 转录因子 FoxO1 是叉头家族 O的亚族成员之一,是胰岛素/胰岛素样生长因子信号通路中的关键分子。FoxO1 蛋白主要有磷酸化、 乙酰化和泛素化 3 种不同形式的共价修饰, 这 3 种修饰方式在调节 FoxO1 蛋白分子转录活性和信号转导过程中发挥着重要的作用。FoxO1 在胰岛 β细胞中表达丰富,与其生长增殖、 凋亡、 分化、 应对氧化应激等密切相关。FoxO1 作为胰岛 β细胞中特异的转录因子,研究其在 β细胞中的表达及作用, 将为糖尿病的预防和诊治带来新的契机。 关键词: FoxO1; β细胞;增殖; 分化; 氧化应激 Advancement in Studie s on Transcription Factor FoxO1 in Pancreatic β -Cells ZHENG Shu-j ing, CHEN Nuo-qi. ( Department of Endocrinology, the Affiliated Zhangz hou Municipal Hos pital, Fujian Medical Univer sity, Zhangzhou 363000, China) Abstract: FoxO1, playing a key r ole in INS / IGF-1 ( insulin/ insulin like gr owth factor 1) signa l ing path- way, is one of the O subgroup members in Forkhead family. Ther e are thr ee var ious forms of post-transla tion modifications, namely phosphorylation, acetylation and ubiquitination. These modifica tions contr ibute to the process of signal transduction a nd are involved in the regulation of FoxO1 transcriptional activity. FoxO1 is expr essed in pancr eatic β-cells abundantly, with a close relationship with its pr oliferation, apoptosis, differ en- tia tion, and r esponse to oxidative str ess. The research on FoxO1 , a specific transcription factor in pancr eatic β -cells, will bring a new cha nce in the prevention, diagnosis, and tr eatment of diabetes mellitus. Key word: FoxO1; β -cells; Proli feration; Differ entiation; Oxida tiv e str ess -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 转录因子是控制基因表达的一类蛋白质分子, 对机体组织器官的发