课件：最新重症哮喘最新治疗进展.pptVIP

* 13-14岁人群中重症哮喘高发区域 图中圆形标记的是拉丁美洲，原文的出处是第3页，“centres with the highest prevalence of severe asthma symptoms (7.5%) were mostly found in the English language countries and Latin America”，图中红色聚集的位置正是下页幻灯所提到的巴西 原文的注释是：Figure 2 Prevalence of symptoms of severe asthma according to the written questionnaire in the 13–14 year age group. See text for definition of symptoms of severe asthma. The symbols indicate prevalence values of ,2.5% (blue square), 2.5 to ,5% (green circle), 5 to ,7.5% (yellow diamond) and .7.5% (red star). * 免费向巴西重症哮喘患者提供吸入性糖皮质激素（ICS）后，住院率显著下降，政府及家庭的医疗费用均下降，医疗负担减轻。 原文的注释是：FIGURE 2. Asthma hospitalisation rates ($), the number of patients enrolled in the Programme for Control of Asthma in Bahia (h) and the number of dispensed units of medication containing inhaled corticosteroids () as a single medicine or in combination in Salvador, Brazil from 2002 to 2006. ICS: inhaled corticosteroids. * GINA2014指南第36页最上方 * * * 过敏性支气管肺真菌病 allergic bronchopulmonary mycoses (ABPM) 阿司匹林加重呼吸系统疾病 aspirin-exacerbated respiratory disease (AERD) 过敏性支气管肺曲霉菌病 Allergic Bronchopulmonary Aspergillosis（ABPA） 有关哮喘表型和内型的原文摘要解释如下： A phenotype is defined as the integration of different characteristics that are the product of the interaction of the patient’s genes with the environment. Both clinical and statistical approaches have identified at least 3–5 phenotypes of severe asthma. However, these phenotypes, in isolation, do not identify the immunopathology that makes these clinical phenotypes distinct or identifies a target population for a specific approach to therapy. As biological characteristics are identified, phenotypes should continue to evolve towards asthma endotypes. The identification of these endotypes, either by matching biology, genetics and therapeutic responses to therapy with clinically or statistically defined phenotypes or through unbiased genetic and genomic approaches, remains limited. * exercise-induced asthma (EIA) 运动诱发型哮喘 aspirin-exacerbated respiratory di