类胡萝卜素对K562细胞和PPARγ蛋白表达的影响-应用化学专业论文.docxVIP

郑州大学硕士学位论文 郑州大学硕士学位论文 摘要 Abstract Carotenoids are a large class of tetraterpenes compounds by means of carbon atoms having alternate link of single bonds and double bonds as the centre frame．They not only are natural pigcnents，but also play important roles in human health and nutrition，such蕊， antioxidant and anticancer roles．And strong evidence suggests that diets rich in earotenoids can prevent the onset of some chronic diseases，such as preventing,delaying,and treating ischemic heart diseases，Some tumors，immunodeficiency,aging,cataract，and light sensitive diseases．The supplemental and clinical applications of B-carotene which has the greatest provitamin A activity and been most widely used as a coloring agent and micronutrient in food have got accredits from the experts Of WH0．EEC,FDA,and Japan．Carotenoids can induce the communication among cells．Tllis is able to lead to the inhibitory effect of the proliferation of transforming cells，but also to the inhibitory effect of the growth of some tumor cells，such as breast cancer,adenocarcinoma，neurokeracele and leukemia cells(HL-60)． A great deal of interest has been given to the understanding of the mechanisms of action by which carotenoids may modulate physiological functions and influence cell growth．It has been shown that carotenoids CaR inhibit the growth of chronic myelocytic leukemia(CML) cells．but little is known about the molecule mechanisms of action of carotenoids． The peroxisome proliferators-activated receptors(PPARs)are well—characterized transcription factors that are members of the nuclear hormone receptor superfamily．There are three PPARs subtypes(PPAR％PPAR Y，and PPARS)．Relationship between PPART and c蚰cc格has been paid attention to recently．It has been reported that the expression of PPART is up-regulated in many tumor cells．PPART is an important target for the development of new drugs aimed at preventing and treating cancel Ligands for PPAR7 suppress carcinogenesis in experimental models and induce the