利多卡因对点燃模型的作用-药理学专业论文.docxVIP

筮二重虫塞翅墨关键词 筮二重虫塞翅墨 关键词 利多卡因：杏仁核点燃：化学点燃：丙戊酸钠；癫痫 2 THE THE EFFECT箍三童羞毫撞墓一0F LIDOCAINE ON EPILEPTIC MODELS ABSTRACT As a kind of part-anesthetic drug，lidocaine was chemically manufactured in 1 920s，but its extensive and specific pharmacological effect，especially the dual effects on central nerve system has been carefully investigated in recent ten years． This article has discussed its effect on several epilepsy models and studied its acting mechanism．The results are as following． 1 Successfully made the amygdala kindling model of rats． 2 Lidocaine 5．0—25 mg‘kg—ip can inhibit the seizure of kindled rats，raise the threshold，reduce Racine’S stages(P0．05)．Lidocaine，at the dose above 30 mg’kg～， shows the significant excitory effect on kindling． 3 When combined with valproate at an ineffective dose 50 mg‘kg～ip，lidocaine can reduce Racine’S stage(PO．05)． 4 Successfully made the lidocaine chemical-kindling model，discussed the relation of chemical-kinding and doses of lidocaine，drug-administration plans， animal species． 5 Studied several kinds of anti·repilepsy drugs on lidocaine·-induced chemical—kindling model． 6 In electricity—stroke model of mice．1idocaine 20-40 mg‘kg。‘ip can significantly prolong latent period(P0．05)． These resuhs show．that lidoeaine has excitory and inhibitory effects on amygdala kindling models and has synergic effect、Ⅳith valproate．the mechanism probably is rOlated to enhancing the function of GABA system如d inhibiting Na+ channel．Lidocaine is a kind of chemical-kindling agenL its mechanism and characteristic are different form general drugs(such as PTZ)．These results provide the basis of lidocaine’S pharmacological mechanism and reasonably drug·administration，especially combined administration of anti-epilepsy drugs；also 3 ： ： 箍三童墓塞摘要 do some help to the study of epileptic pathogenesis Ma Chuan·xin(pharmacology) Directed by Yue Wang，Ji So