英国纽卡斯尔大学 药理学课件.pptVIP

Agonists and dose-response curves - a recap An agonist is a ligand (drug, hormone or transmitter) that combines with receptors to elicit a cellular response Two types of dose response relationship GRADED QUANTAL The higher the potency, the lower the EC50 (cf relationship between affinity and Kd) Full agonists have high efficacy Partial agonists have lower efficacy The results shown below were obtained in a comparison of positive inotropic agents (drugs used in heart failure to increase cardiac contractility). Which statement is correct? Drug A is most effective Drug B is least potent Drug C