杀菌剂腈苯唑的合成工艺研究-化学工程专业论文.docxVIP

浙江大学硕士研究生毕业论文 浙江大学硕士研究生毕业论文 Abswaet Abstract The fenbuconazole is a hi【gh efficient fungicide．A route was proposed here,and it started from 2-(4-chlorophenyl)acetic acid as a law material，through six reactions included esterify, reduction,chlorination,two times of nucleophilic reactions and condensation reaction, fenbuconazole was eventually prepared．And锄optimization of preparation technique Was obtained in this paper,by wich could reach a hie,h yield of fenbuconazole． 2一(4-chlorophenyl)ethanol Was obtained by the reduction ofethyl 2-(4-cb_lorophenyl) acetate which obtained from esterifying of 2·(4-chlorophenyl)acetic acid．A favorite reaction condition Was obtained after we studied the influence of amount of SOCl2，NaBH4 and reaction temperature．Thus，the yield of the two steps reached 95％．In this paper,we developed a novel route,combined esterify and reduction reaction in one-pot，which simplified the operation and reached a hi班yield ofproduct． 2·(4一chlorophenyl)·1-ehloroethane Was obtained by the reaction with SOCl2．Pyridine Was used as a catalyst．A favorite reaction condition Was obtained after we studied the influence ofamount ofSOCl2．Thus，the yield ofproduet reached 96％． 4一f4一chlorophenyl)-2-phenyl-butanenitrile was obtained by the reaction with 2-(4-ehlorephenyl)一1-chioroethane．NaH Was used勰reaction base．A favorite reaction condition Was obtained after WO studied the influence of虹nd of base．amount of reagent, ratio ofreactant and reaction temperature．Thus，the yield of4-(4-ehlorophenyl)-2一phenyl— butanenitrile reached 82％，which WaS much higher than it was reported． 2-bromomethyl-4-ehlorophenyl-2一phenyl-butanenitrile Was obtained by the reaction with dibromomethane．30％NaOH Was used雒reaction base．A favorite reaction condition Was obtained after we studied the influence ofconcentration ofbase,amount ofreagent，ratio ofreactant and temperature．Thus，the yield of2-bromomethyl-4-ehlorophenyl一2-phanyl- butanenitrile reached 93％． Fenbuconazole Was eventually obtained by th