探讨同型半胱氨酸和血栓调节蛋白与原发性高血压并脑梗塞的关系.docVIP

探讨同型半胱氨酸和血栓调节蛋白与原发性高血压并脑梗 塞的关系 望奎县人民医院152100 目的 研究分析血清同型半胱氨酸(homocysteine, HCY)、血栓调节 蛋口 (plasma thrombomodulin, PTM)与原发性高血压并脑梗塞患者的关系。方 法此次研究的对象是选择采用酶联免疫吸附实验测定40例原发性高血压并脑 梗塞患者组、30例原发性高血压及30例正常对照组。对三组患者取空腹静脉血 清测定同型半胱氨酸、血栓调节蛋口。结果原发性高血压并脑梗塞患者组血清 HCY、PTM水平高于原发性高血压组，显著高于正常对照组；血浆HCY与PTM 水平呈显著的正相关；HCY、PTM及收缩压是影响原发性高血压并脑梗塞患者血 管内皮损伤的主要危险因素。结论高HCY血症是高血压并脑梗塞患者的一个独 立危险因素，血清血栓调节蛋白水平是反应血管内皮细胞受损程度的良好指标, 联合检测血浆HCY和PTM水平，有助于预测高血压及心脑血管疾病的危险性。 关键词原发性高血压；脑梗塞；同型半胱氨；血栓调节蛋口 [Abstract]Objective To study the relationship between serum homocysteine (homocystei ne, HCY), thrombomoduli n, PTM (plasma) a nd primary hyperte nsion and cerebral infarction patients.Methods the subjects of this study were selected from 40 cases of primary hypertension and cerebral infarction group. 30 cases of primary hypertension and 30 cases of normal control group by ELISA.Three groups of patients were taken to determine the serum homocysteine，blood serum.The results of primary hypertension and cerebral infarction group, the serum HCY level of PTM was higher than that of primary hypertension group was sigrdficantly higher than that in normal control group； plasma HCY was positively correlated with the level of PTM； HCY，PTM and systolic blood pressure is the main factors affecting the risk of cerebral infarction patients with endothelial injury and primary hypertension.Conelusion high HCY hyperlipidemia and hypertension is an independent risk factor in patients with cerebral infarction, serum thrombomodulin level is a good indicator of response to vascular endothelial cell damage, combined detection of plasma HCY and PTM levels, the risk is helpful to the prediction of hypertension and cardiovascular and cerebrovascular diseases. ［Key wordsjprimary hypertensive cerebral infarction, cerebral infarction, homocysteine，homocysteine, blood clot 高血压是以体循环压增加为主要表现的临床综合症，是多种基因因素和环境 因素共同作用的结果。目前我国高血压病处于患病率和发病率高、知晓率，治疗 率低，控制率低的严峻局面。在发病、治疗与控制状况方面更令人担忧。在我国 高血压每年导致大约210万人死亡。高血压是最常见的心脑血管疾病，是全球范 围内最重大的公共卫生问题之一。经研究证实在高血压的发病及进展过程既有