老年病学实践老年神经系统疾病.ppt

* Figure 2. Putative Amyloid Cascade. This hypothesis of the amyloid cascade, which progresses from the generation of the beta-amyloid peptide from the amyloid precursor protein, through multiple secondary steps, to cell death, forms the foundation for current and emerging options for the treatment of Alzheimers disease. APP denotes amyloid precursor protein, and A beta-amyloid * The classic clinical features of Alzheimer’s disease are an amnesic type of memory impairment？？？, deterioration of language,and visuospatial deficits. Motor and sensory abnormalities, gait disturbances, and seizures