熊去氧胆酸与丁二磺酸腺苷蛋氨酸联合治疗乙型肝炎合并妊娠期肝内胆汁淤积症的效果观察.docVIP

I1 与丁二?跆縮乙劉环 I1 I1 WWS肝内睚憫蔣 2018-04-08 09:50:18中国现代医牛2018年4期 王海燕哈丽亚?哈力木别克 ［摘要］戸的探討在乙型肝炎合并妊娠期肝内胆汁淤积症(ICP)患者中联合应用熊去氧胆酸与 丁二磺酸腺昔蛋氨酸的临床效果。方法选取108例乙型肝炎合并ICP患者，按照随机数字表法分 为常规组和联合组，分别给予单纯丁二磺酸腺甘蛋氨酸和抗乙型肝炎病毒(HBV)治疗，在常规组疗 法的基础上联合熊去氧胆酸治疗。比较治疗前后症状积分和血清生化指标、临床疗效和不良反应。结 果治疗后两组症状积分均较治疗前降低(PvO.05),且联合组积分低于常规组(PvO.05)；治疗后 两组谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)和总胆汁酸(TBA)均较治疗前 降低(PvO.05),且联合组水平低于常规组(PvO.05)；联合组综合疗效分布与常规组比较，差异 有统计学意义(PvO.05),且联合组临床有效率高于常规组(PvO.05)；联合组不良反应发生率稍 高于常规组，差异无统计学意义(P0.05)。结论对乙型肝炎合并ICP患者联合给予熊去氧胆酸 和丁二磺酸腺昔蛋氨酸治疗能够显著减轻症状和肝功能损害，增强疗效，且并不会明显增多不良反应。 ［关键词］熊去氧胆酸；丁二礦酸腺昔蛋氨酸：乙型肝炎：妊娠期肝内胆汁淤积症 ［中图分类号］R714.25 ［文献标识码］A ［文章编号］1673-9701 (2018) 04-0016-04 ［Abstract］ Objective To investigate the clinical effect of ursodeoxycholic acid combined with ademetionine 1, 4-butanedisulfonate in the patients with hepatitis B complicated with intrahepatic cholestasis during pregnancy (ICP) . Methods 108 patients with hepatitis B complicated with ICP were divided into routi ne group and combi nation group accordi ng to ran dom nu mber table. The patients were given simple ademetionine 1, 4-butanedisulfonate and anti-hepatitis B virus (HBV) treatment, and were given combined ursodeoxycholic acid on the basis of treatment in the routine group. The symptom scores and serum biochemical indicators before and after treatment, clinical efficacy and adverse reactions were compared. Results After treatment, the symptom scores of both groups were lower than those before treatment (P0.05) , and the scores in the combi nation group were lower than those in the routine group (P0.05) ； after treatment, ALT, AST, TBIL and TBA were lower than those before treatment in both groups (P0.05) , and the levels in the combi nation group were lower than those in the routi ne group (P0.05) ； the differe nces were statistically sign ifica nt in the distributi on of comprehe nsive efficacy between the combi nation group and the routi ne group (P0.05), and the clin ical effective rate in the combi nation group was higher than t