环孢素A对难治性肾病综合征患者外周血T淋巴细胞亚群的影响研究.docVIP

环抱素A对难治性肾病综合征患者外周血T淋巴细胞亚群的影响研究 周小燕(电白县屮医院肾内科广东茂名525400) 【摘要】目的 分析研究环孑包素A对难治性肾病综合征患者外周血T淋巴细胞亚 群的影响。方法 将2010年4月?2012年11月于本院进行治疗的40例难治性 肾病综合征患者为研究对象，将其遵循随机数字表法分为对照组(常规治疗组) 20例和观察组(常规治疗+环抱素A组)20例，然后将两组患者治疗前与治疗后 不同时间点的外周血T淋巴细胞亚群的四个指标进行比较。结果 观察组治疗后 不同时间点的外周血T淋巴细胞亚群四个指标改善程度均显著地优于对照组，P 均V0.05,均有显著性差异。结论 环抱素A对难治性肾病综合征患者外周血T 淋巴细胞亚群的影响较大，更有利于患者的康复。 【关键词】环孑包素A难治性肾病综合征 外周血T淋巴细胞亚群 影响 【中图分类号】R453 【文献标识码】A 【文章编号】2095-1752 (2013) 14-0156-01 Study on the in flue nee of cyclospori n A for the peripheral blood T lymphocyte subsets of patients with refractory nephrotic syndrome ZHOU Xiaoyan Department of Nephrology, TCM Hospital of Dianbai County, Guangdong Provinee, Dianbai 525400, China [Abstract] Objective： To an alyze and study the in flue nee of cyclospori n A for the peripheral blood T lymphocyte subsets of patients with refractory nephrotic syndrome.Methods： 40 patients with refractory nephrotic syndrome who were treated in our hospital from April 2010 to November 2012 were the research object, and all the patients were divided into control group (routine treatment group) 20 cases and observation group (routine treatment and cyclosporin A group) 20 cases according to the random number table, then the two groupsprime; four indexes of peripheral blood T lymphocyte subsets before the treatment and at different times after the treatment were compared.Results： The observation groupprime;s four indexes of peripheral blood T lymphocyte subsets at different times after the treatment were all sigrdficantly better than those of control group, all P0.05, there were all significant differences.Conclusion： The influence of cyclosporin A for the peripheral blood T lymphocyte subsets of patients with refractory nephrotic syndrome is great, and it is more helpful for the rehabilitation of patients. 【Key words] cyclosporin A refractory nephrotic syndrome peripheral blood T lymphocyte subsets in flue nee 肾病综合征患者的发病原因中免疫方面的紊乱是重要的一类，因此对其 治疗的过程中也应重视对其免疫方面的调节，而难治性肾病综合征的治疗则对此 方面尤其应引起重视。临床中对于难治性肾病综合征的治