结直肠癌的免疫治疗再思考.pptx

结直肠癌的免疫治疗再思考;声明;内容;内容;*KRAS WT 肿瘤. NOTE:非正式比较，非头对头研究. 5-FU, 5-fluorouracil; FOLFIRI, 5-FU + LV + irinotecan; FOLFOX, 5-FU + LV + oxaliplatin; FOLFOXIRI, 5-FU + LV + oxaliplatin + irinotecan; IFL, irinotecan/bolus 5-FU/LV; LV, leucovorin; XELOX, capecitabine + oxaliplatin. 1. Saltz. 2000; 2. Douillard. 2000; 3. Goldberg. 2004; 4. Hurwitz. 2004; 5. Saltz. 2008; 6. Falcone. 2007; 7. Bokemeyer. 2011; 8. Van Cutsem. 2011; 9. Douillard. 2011; 10. Passardi. 2013; 11. Heinemann. 2013; 12. Venook. 2014; 13. Loupakis. 2015.;CRC信号通路复杂，全球范围内靶向药物研发缓慢;难治性CRC的靶向治疗研究（Completed）;难治性CRC的靶向治疗研究（ongoing）;免疫治疗成