Introduction of Nuclear Molecular Imaging in personalized oncology-8年制创新班整合课程.ppt

分子影像学：在细胞和分子水平对生物学过程的活体评定和测量 --Weissleder，1999 分子影像学 ——疾病基础的分子异常 * * * * * Hit: * Optical Imaging: Radiations in the optical and near infrared regions (NIR) * * * * * * * * ⅱ The Role of 18FDG PET/CT in Oncology 4. Image-guided Radiation Therapy Planning 18F-FDG PET/CT has been shown to improve disease diagnosis and staging, assist in tumor volume delineation, define tumor phenotype or biological tumor volumes, to assess treatment response and in-beam monitoring of radiation dosimetry. * ⅱ The Role of 18FDG PET/CT in Oncology 4. Image-guided Radiation Therapy Planning —Role of PET/CT imaging in Radiotherapy Planning ★ Tumor staging (up or down) - change in treatment intent ★ Treatment field modifications - inclusion of locoregional nodal disease ★ Localised symptom control ★ Sites or residual or metastatic disease ★ Therapy response evaluation * Radiotherapy Planning Radiopharmaceutical Tumor Biology Clinical Applications 18F-FDG Glucose Metabolism All tumors 11C-methionine 11C-choline 18F-DOPA 18F-methyltyrosine (MET) Proteins/amino acids Brain tumour Prostate cancer Carcinoid tumour Musculoskeletal tumour 18F-thymidine (FLT) DNA Proliferation Treatment response (all) 18F-annexin V Apoptosis Treatment response (all) 18F-misonidazole (FMISO) Hypoxia Radiation planning (all) 18F-estradiol Receptor binding Breast cancer 18F-acetate Membrane/lipid synthesis Hepatocellular carcinoma Table 1. Non-FDG PET radiopharmaceuticals used in oncology * ⅱ The Role of 18FDG PET/CT in Oncology Case 1 PET/CT for tumor delineation of the metabolically active component of the CT abnormality, with different doses seen on the second row contour margins. * ⅱ The Role of 18FDG PET/CT in Oncology Case 2 (A) MRI showed bilateral asymmetry structure of the nasopharynx, the delineation of biological target was drawed . (B) PET/CT showed biger high metabolic lesion than MRI displayed, the biological target of radiotherapy was re-adjusted. * ⅱ The Role of 18FDG PE