传染性单核细胞增多症 Infectious Mononucleosis.ppt

Differential Diagnosis 1. suppurative tonsillitis 2. infectious mononucleosis-like syndrom 3. viral hepatitis 4. Kawasaki disease 5. Leukemia Treatment 1. general treatment 2. symptomatic treatment 3. antiviral therapy：α-interferon、Acyclovir Ganciclovir 4. the use of glucocorticoid： indicator Prognosis 1.most good prognosis 2.few patients prolonged course 3.1% of patients die * * * * Infectious Mononucleosis (IM) mono Introduction Infectious mononucleosis(IM) is an infectious disease caused by Epstein-Barr virus(EBV) . The clinical features include fever, pharyngitis , and generalized lymphadenopathy. The characteristics of lab study is atypical lymphocytosis in the peripheral blood. EBV associated disease The upper respiratory tract infection Infectious mononucleosis(IM) EB Virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) Chronic active EBV infection EB Virus-associated malignant tumor (Burkitt lymphoma 、B cell lymphoma、Hodgkins disease, nasopharyngeal carcinoma ) Etiology Epstein-Barr virus(EBV) 1. Classification： double-stranded DNA virus ---Family: Herpesviridae ---Subfamily: γ-herpesvirinae 2. Characteristics of EBV Latent-reactive Lymphotropic virus just infecting B-LC capacity to have B lymphocyte proliferate infinitely (immortalization ) Epstein-Barr virus(EBV) Etiology 3、Viral Antigen Systems viral capsid antigen, VCA EB nuclear antigen, EBNA early antigen, EA lymphocyte-detected membrane antigen, LYDMA membrane antigen, MA Epidemiology 1. Infectious sources Patients, persons with latent infection and carriers 2. Routes of transmission ： Contact transmission through the mouth (exchange of saliva) blood transmission occasionally 3. Population susceptibility School age children and adolescents 4. Epidemiological features Peak seasons Epidemiological status 传染性单核细胞增多症及其相关疾病临床特点分析,中国实用儿科杂志,2003年12月第18卷12期 儿童传染性单核细胞增多症临床特点与发病年龄的关系附312例临床