2型糖尿病药物治疗的新进展课件.pptVIP

符合生理的胰岛素治疗方案 胰岛素治疗的目的在于模拟生理性胰岛素释放 基础加餐时胰岛素 胰岛素水平(mU/L) 时间(h) 餐时 餐时 餐时 基础胰岛素需求 餐时胰岛素需求 McCall AL. In: Leahy JL, Cefalu WT, eds. Insulin Therapy. New York, NY: Marcel Dekker, Inc; 2002:193-222. Bolli GB et al. Diabetologia. 1999;42:1151-1167. 各种胰岛素的药物动力学 Insulin Onset Peak Duration Regular 30-60min 2-3h 8-10h Aspart 10-20min 40-50min 3-5h Lispro 5-15min 30-90min 4-6h Glargine 2-4h Relatively flat up to 24h Detemir 0.8-2h Relatively flat up to 24h Biphasic human insulin 50/50 0.5-1h 2-12h 18-24h Biphasic human insulin 70/30 0.5-1h 2-16h 18-24h Biphasic humanaspart 70/30 10-20min 1-4h up to 24h B