尿酸氧化酶降尿酸药物.pptVIP

New anti-inflammatory strategies Canakinumab, a monoclonal antibody, neutralizes IL-1β to suppress inflammation. （avoid interleukin-1 blockers in patients with active infection） Anakinra is a recombinant human IL-1β receptor antagonist that is FDA-approved for rheumatoid arthritis and neonatal-onset multi-system inflammatory disease. Igel TF,etal.. Recent advances in understanding and managing gout. F1000Res. 2017 Mar 10;6:247. 康纳单抗 阿那白滞素 降尿酸药物 抑制尿酸生成的药物—黄嘌呤氧化酶抑制剂 嘌呤类：别嘌醇、奥昔嘌醇 非嘌呤类：非布司他 促进尿酸排泄的药物 促尿酸肾脏排泄药：苯溴马隆、丙磺舒、苯磺唑酮 促尿酸肠道排泄药：活性炭类的吸附剂 促进尿酸分解的药物——尿酸氧化酶 降尿酸药物 降尿酸药物无抗炎作用，不用于急性痛风关节炎 Prevention