不同剂量丙种球蛋白治疗重症手足口病患儿疗效研究.docxVIP

不同剂量丙种球蛋白治疗重症手足口病患儿疗效研究 ［摘要］目的探讨不同剂量的丙种球蛋白治疗重症 手足口病患儿的疗效。方法选取2009年3月?2013年3 月来院就诊的重症手足口病患儿97例，分为3组。在基础 治疗的基础上，A组给予IVIG 0. 2 g/ (kg ? d)治疗；B组 予IVIG lg/ (kg ? d)治疗。C组予羚羊角粉治疗。结果A、 E两组患者NSS好转、发热缓解、临床治愈时间比较，差异 均无统计学意义(P0. 05)o A、B两组与C组比较，NSS好 转、发热缓解、临床治愈时间比较，差异均有统计学意义 (P0. 05)o结论 及早使用IVIG对手足口病患儿疗效显著; 使用大、小剂量IVIG治疗重症手足口病疗效相近。 ［关键词］丙种球蛋白；重症手足口病；疗效 ［中图分类号］R729 ［文献标识码］B ［文章编号］ 2095-0616 (2013) 13-71-02 Analysis of different dose of gamma globulin in treatment of severe HFMD effect YU Huajuanl LIANG Yinzhi2 1. Department of Pediatrics , Long，an County People s Hospital , Long， an 532700 , China ； 2. Department of Preventive Care , Long? an County People， s Hospital, Long an 532700, China [Abstract] Objective To study the curative effect of children with different dose of gamma globulin in the treatment of severe hand-foot-mouth disease. Methods 97 cases in the hospital with severe hand foot and mouth disease in, from 2009 March to 2013 March were divided into 3 groups? On the basis of conventional treatment, A group was given IVIG 0. 2g/ (kg ?d) treatment； group B was treated with IVIG lg/ (kg ?d) treatment ? C group was t reated with ant elope horn powder. Results NSS improving, fever, alleviate clinical cure time comparison between A and Bgroup, the difference was not sta/tistically significant (P0.05)? But NSS improved , fever , alleviate clinical cure time comparison among A, B two group and C group, the differences were statistically significant (P0.05)? Conclusion Early use of IVIG significantly in children with hand-foot-and-mouth disease curative has effect； The use of large, small doses of IVIG had similar effect in treatment of severe hand-foot-mouth disease? _Key words] Gamma globulin； Hand-foot-and—mouth disease； Curative effect 手足口病(Hand-foot-mouth Disease, HFMD)是由多 种肠道病毒引发的急性的传染病，主要临床特征为发热、口 腔疼痛性水疱以及手足疱疹，是一种比较常见的儿科传染 病。本病传染性强，传播快，短时间可造成大流行［1］。本 研究选取2009年3月?2013年3月来院就诊的重症手足口 病患儿87例，采用不同剂量的丙种球蛋白(IVIG)治疗， 报道如下。 1资料与方法 1. 1 一般资料 选取2009年3月?2013年3月来院就诊的重症手足口 病患儿87例，