外泌体与肺癌脑转移瘤关系的研究进展·综述-中国肿瘤临床.PDFVIP

404 中国肿瘤临床2017年第44卷第8期 ChinJClinOncol2017.Vol.44.No.8 综 述 · · 外泌体与肺癌脑转移瘤关系的研究进展 党莹 孙红军 林瑜亮 综述 荔志云 审校 摘要 外泌体（extracellularvesicles，EVs）是各类细胞（尤其是肿瘤细胞）释放的一种能介导遗传物质传递的磷脂双层膜的囊泡样 小体。外泌体中含有受体、蛋白质和核酸，具有携带肿瘤遗传物质，调节肿瘤微环境，促进肿瘤血管生成及介导肿瘤细胞转移等 功能。目前研究发现外泌体与肺癌脑转移瘤关系密切。外泌体介导的肺癌脑转移主要包括调节脑部预转移巢微环境，破坏血脑 屏障，调节瘤细胞病理特征等过程。外泌体与肺癌脑转移瘤关系的研究为肺癌脑转移瘤的发生发展、临床诊断和治疗研究提供 了更多分子靶点。 关键词 肺癌脑转移瘤 外泌体 转移巢 转移机制 靶向治疗 doi:10.3969/j.issn.1000-8179.2017.08.080 Research progress on relationship between brain metastasis from lung cancer and ex- tracellular vesicles Ying DANG, Hongjun SUN, Yuliang LIN, Zhiyun LI Correspondence to: Zhiyun LI; E-mail: lizhiyun456@ 163.com Department of Neurosurgery, Lanzhou General Hospital, Lanzhou 730050, China Abstract Extracellular vesicles (EVs) are vesicles like body of phospholipid bilayer membrane, which are able to mediate the transfer of genetic material. There are receptors, proteins and nucleic acids in the body, with carrying tumor genetic material, regulating tumor microenvironment, promoting tumor angiogenesis and mediating tumor cell metastasis. At present, it is found that there is a close re- lationship between the secretion and the metastasis of lung cancer. The main aspects of the brain metastasis of the lung cancer medi- ated by the exocrine body include the regulation of the microenvironment of the brain, the destruction of the blood-brain barrier, and the regulation of tumor cell pathology. The study on the relationship between the tumor and the metastasis of lung cancer may pro- vide more molecular targets for the development, diagnosis and treatment of lung cancer. Keywords: brain metastases from lung cancer; extracellular vesicle; metastatic niche; transfer mechanism; target therapy 肺癌脑转移瘤是临床最常见的脑转移瘤，约占 传物质，且表面含有特异性受体结构，可特异性地与特 ［1］ ［4］ 脑转移瘤的19.9% ，其中首诊的肺癌患者中约10%， 定组织细胞结合后发生融合，并使其获得癌细胞特性 。 在肺癌