恶性胸腔积液中CD4T细胞的研究进展.PDFVIP

2014 41 5 Cancer Res Prev Treat,2014,Vol.41,No.5 501 肿瘤防治研究 年第 卷第 期 · · doi:10.3971/j.issn.1000-8578.2014.05.036 恶性胸腔积液中CD4+T细胞的研究进展 宫 原，陈世雄 Review on CD4+T Cells in Malignant Pleural Effusion GONG Yuan, CHEN Shixiong Department of Respiratory Medicine,The First College of Clinical Medical Science,China Three Gorges University, Yichang Central People’s Hospital,Yichang 443003,China Corresponding Author: CHEN Shixiong, E-mail:236766535@ Abstract:Cellular immunity is an important part of human immune system, mainly mediated by CD8+ cytotoxic T cells and CD4+ helper T cells. CD4+T cells include many subsets, for example, Th1 and Th2 cells, and the newly discovered subsets include Treg, Th17 and Th9 cells which are all involved in the tumor immune reaction at different degrees. But the mechanisms of inhibiting or promoting tumors remain unclear. This review collected the latest information of CD4+T subsets in malignant pleural effusion, including their changes, the possible mechanism, their roles in the tumor immune reaction, and provided a new targets for diagnosis and treatment of tumor. Key words: Regulatory T cell;T helper 17;T helper 9;Pleural effusion CD8 T CD4 T ：细胞免疫是人体免疫系统的重要组成部分，主要由 ＋细胞毒 细胞及 ＋辅助性 细胞 CD4 T Th1 Th2 介导机体免疫反应，其中 ＋ 细胞又包括多个亚群，如 、 细胞，目前又发现了新的亚群 如Treg 、Th17 、Th9 ，均不同程度参与了疾病的免疫过程，而对于肿瘤的抑制或促进作用机制尚不清 CD4 T 楚。本综述收集了恶性胸腔积液中有关 ＋ 亚群变化及可能机制的最新资料，分析其在肿瘤中的 特性和作用以了解在肿瘤局部微环境的效应机制，为肿瘤的诊断治疗提供新的靶点。 T Th17 Th9 ; ：调节性 细胞；辅助性 细胞；辅助性 细胞 胸腔积液 ：R734.3 ：A 0 1.1 Th1细胞 CD4 T IL-1