AI-2群体感应系统抑制剂细菌生物膜感染的潜在新药.docVIP

AI-2群体感应系统抑制剂: 细菌生物膜感染的潜在新药 夏培元，史惠卿 （400038 重庆，第三军医大学西南医院药剂科） [关键词] 生物膜；群体感应系统；luxS/AI-2；细菌耐药；毒力因子 [中图法分类号] [文献标志码] A AI-2 quorum sensing inhibitors: potential drug to bacterial biofilm infections [Abstract] Bacterial biofilms possess strong drug resistance and can evade from immune attack, resulting in chronic infection, which is difficult to control and can’t be effectively treated by conventional anti-infective therapy. In the study of finding an effective drug therapeutic target for anti-biofilm, bacterial quorum sensing (QS) system has been attached great importance. QS system is an important signal regulatory system of bacterial cells and it participates in a large number of gene expressions. AI-2 QS system is widespread in gram-positive bacteria and gram-negative bacteria, which is the only currently-known intra- and interspecific QS signal transduction system. The phaenotypes of AI-2 QS system include luminescent effect, locomotory capacity, biofilm formation, release of virulence factors. QS suppression system may inhibit bacterial biofilm formation and significantly affect the expression of bacterial toxin or virulence. This provides a new research direction for the prevention and control of bacterial biofilm infection. This article reviews the progress of AI-2 QS system inhibitors and discusses its potential as a new anti-infective therapy . [Key words] biofilm; quorum sensing; luxS/AI-2; bacterial resistance; virulence factors Corresponding author: Xia Peiyuan, Tel: 86-23 E-mail: peiyuan_xia@ [通信作者] 夏培元，男，教授，博士生导师。任全军医学科技“十二五”发展计划编制专家组成员、国家卫生部和食品药品监督局“药物临床试验机构”认证特聘专家、中国药理学会药学监护专业委员会副主任委员、全军第九届药学专业委员会临床药理专业分委会副主任委员、全军第九届科学技术委员会药学专业委员会常务委员、全军第九届科学技术委员会医院感染学专业委员会委员、中国人民解放军总后勤部直属单位药学专业委员会副主任委员、重庆市医学会临床药学委员会主任委员、重庆药学会医院药学专业委员会主任委员和多家国内杂志常务编委或编委；主持并完成包括国家863、国家重大新药创制在内的十余项重大项目；获得重庆市科技进步二等奖1项（2009年）、军队医疗成果二等奖1项（2006年）；近三年来在国外SCI收录杂志发表论文15篇。主要从事细菌对抗菌药物耐药的分子基础及其感染防治的研究，电话：（023 E-mail: peiyuan_xia@ 细菌生物膜(biofilm)