不同时期小剂量辣椒素对大鼠胃动力的作用与机制分析.pdfVIP

(P0．05)。 17、 56．243土1 果：光镜下观察：各组大鼠胃上皮细胞形态正常，排列整齐，胞质透明或 呈空泡状，未见粘膜脱落、充血、水肿、炎性细胞浸润及腺体结构紊乱或 坏死。根据Masuda标准对胃黏膜病理损伤程度进行评分，病理损伤积分 固有层中。A1组、B1组、A2组与A3组中阳性产物量少，着色浅，分散， 分泌产物显著增多，着色较深呈颗粒状，分布均匀，固有层中也有较多产 万方数据 周)摄入小剂量CAP对大鼠胃动力有明显的促进作用。3．长期摄入d,N量 4．长期摄入小剂量CAP不会对大鼠胃粘膜造成损害。 关键词：辣椒素；胃动力：MTL；TRPVl；SP；CGRP 万方数据 Researchoftheeffectsandmechanismsofsmalldose 011 capsaicin indifferent rats’gastricmotility periods Abstract： theroleofsmalldose Objective：Toexplore rats’gastricmotilitythroughtestingmigratingmyoelectric and rateindifferent theroleofCAPon gastricemptying periods；toexplore mucosalbarrier the of gastric throughobservinghistologychangesrats’gastric themechanismsofCAP the motilin mucosa；toexplore throughtestingplasma the oftransient level，evaluatingexpression receptorpotentialtypeI(TRPV1)， substance mucosa． P(SP)，calcitoningene—relatedpeptide(CGRP)inrats’gastric 60 were Methods：(1)Thegrouping：Totally dividedintotwo control A)and randomly groups：：the group(group had30rats．Thecontrol were B)，each group experimentalgroup(groupgroup diet．In fedwithnormaldietandthe werefedwithCAP experimentalgroup orderto theeffectsofCAPon