回生口服液对卵巢癌患者化疗疗效及凝血功能的影响.docVIP

回生口服液对卵巢癌患者化疗疗效及凝血功能的影响 王毅峰1 宋文广2 范扶民1 王瑞林2 赵金红1 1河北省唐山市工人医院妇产科，2 河北省唐山市工人医院放化疗科（唐山 063000） 【摘要】目的 探讨回生口服液联合一、二线化疗治疗卵巢癌的疗效及其对凝血功能的影响。方法 符合化疗条件的92例卵巢癌患者自愿加入服药组（49例）或对照组（43例），两组均按照临床实践指南给予一/二线化疗，服药组在化疗同时加服回生口服液10ml 3/日，观察治疗前后血常规、肝肾功能及凝血系列等指标，参照RECIST或Rustin评价标准评价近期疗效和疾病进展时间（PFS），并比较两组凝血功能的变化。结果 服药组33例(67.3%)CR，6例(12.2%) PR，客观有效率（RR）79.6%；对照组27例(62.8%)CR，5例(11.6%)PR，RR 74.4%，两组有效率比较，χ2=0.348，P=0.555，无显著性差异；服药组和对照组的平均PFS分别为32.2月和26.7月，χ2=1.877，P=0.171，统计学差异不显著；化疗后服药组与对照组比较，PLT、APTT和TT有显著性差异（P0.05）, PT和FIB无显著性差异，服药组化疗前后比较，除FIB之外，其余诸项均有显著性差异。 结论 回生口服液对卵巢癌一/二线化疗的客观有效率和疾病进展时间均有一定提高，对患者的高凝状态有显著改善。 关键词：抗肿瘤 中药治疗 卵巢癌 Effect of Huisheng oral liquid on the curative chemotherapy and blood coagulation function in patients with ovarian cancer Wang Yifeng1 Song Wenguang2 Fan Fumin 1 Wang Ruilin2 Zhao Jihong1 1 department of gynaecology and obstetrics，Tangshan Gongren Hospital，hebei China. 2 department of radiochemotherapy Tangshan Gongren Hospital，hebei China. [Abstract] Objective To investigate the effect of Huisheng oral liquid combined with chemotherapy in first or second line treatment of ovarian cancer and on coagulation function. Methods 92 cases of ovarian cancer patients suitable for chemotherapy volunteered to join the treatment group of 49 cases and a control group of 43 cases, both of the two arms were given chemotherapy according to clinical practice guidelines, and Huisheng oral liquid were given 10ml three times a day in treatment group additionally. The blood routine, liver and kidney function and coagulation series index before and after treatment were observed. The recent efficacy and progress free time were evaluated according to RECIST or Rustin evaluation criteria，and the changes of coagulation function in two groups were compared meanwhile. Results There were 33 cases (67.3%) of CR and 6 cases (12.2%) PR in treatment group, the total response rate (RR) was 79.6%, 27 cases (62.8%) CR and 5 cases (11.6%) PR in control group, RR 74.4%, comparison of efficienc