生物钟基因与疾病Circadian genes and diseases讲课.pptx

生物钟基因与疾病Circadian genes and diseases;;Circadian Rhythm of Sleep;The?term circadian, was coined?by Franz?Halberg;;同步 (Circadian Entrainment);Mouse activity entrains to light;Clock in the Brain;The mammalian circadian timing system;;;Ron Konopka;生物钟基因Clock突变小鼠;;Fergal C et al. Cancer Letters, Volume 342, Issue 1, 2014, 9 - 18;;;;;N Huang et al. Science 2012;337:189-194;N Huang et al. Science 2012;337:189-194;N Huang et al. Science 2012;337:189-194;N Huang et al. Science 2012;337:189-194;Mutations that reduce repression of CLOCK:BMAL1 transactivation by CRY localize to CLOCK PAS-B HI loop. ;NATURE REVIEWS | NEUROSCIENCE VOLUME 4 | AUGUST 2003 | 649;睡眠障碍与生物钟;Daily profiles of expression of clock genes Bmal1, Cry1, Per2 and Rev-erbα in the mouse SCN at the postnatal day 1 (P1), P3, P5.?;Lipids Health Dis. 2010; 9: 22.;Bedont JL,?Blackshaw. Front Syst Neurosci. 2015 May 8;9:74;;MELATONIN;;Explaining shift lag and jet lag;TREATMENT OF CIRCADIAN RHYTHM DISORDERS;生物钟基因与肿瘤;Loning Fu , Helene Pelicano , Jinsong Liu , Peng Huang , Cheng Chi Lee; The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo;Cancer Letters, Volume 342, Issue 1, 2014, 9 - 18;; INTERNATIONAL JOURNAL OF ONCOLOGY 44: 364-370, 2014;生物钟与代谢性疾病;Turek et al. SCIENCE VOL 308 13 MAY 2005 1043;SCIENCE VOL 308 13 MAY 2005 1043;SCIENCE VOL 308 13 MAY 2005 1043;A high-fat (HF) diet lengthens the circadian period in mice. ;Light-phase feeding leads to increased weight gain in mice fed a high-fat diet. ;Science 13 MARCH 2015 ? VOL 347 ISSUE 6227;Diurnal variation of circaidan gene mRNA levels in SCN of C57BL/6J and apoE-/- mice.?;Diurnal variation of circadian gene mRNA in livers of C57BL/6J and apoE-/- mice.;Lipids Health Dis. 2009; 8: 60.;Comparison of Primary Structures of CLOCK and ACTR;HAT Activity Displayed by Immunoprecipitated Myc-mCLOCK;Cell 125, 497–508, May 5, 2006;Schematic Model of CLOCK-Mediated Histone Acetylation and Its Role within the Physiologi