使用超声反向散射表征组织微结构使用高斯形状因子进行优化的理论和技术..pdfVIP

Characterization of tissue microstructure using ultrasonic backscatter: Theory and technique for optimization using a Gaussian form factor Michael L. Oelzea) Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering, University of Illinois, 405 North Mathews, Urbana, Illinois 61801 James F. Zachary Bioengineering Program, University of Illinois, 1406 West Green Street, Urbana, Illinois 61801 William D. O’Brien, Jr. Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering, University of Illinois, 405 North Mathews, Urbana, Illinois and Bioengineering Program, University of Illinois, 1406 West Green Street, Urbana, Illinois 61801 Received 13 December 2001; revised 14 June 2002; accepted 20 June 2002 Characterization of tissue microstructure through ultrasonic backscatter is hypothesized to aid in detection and classification of diseased tissues. Radio frequency signals backscattered from tissues can be modeled according to the assumed shape, size, and distribution of scatterers in tissues. Power spectra of rf backscattered signals describe the frequency dependence of scatterers. Experimental measurements of ultrasonic backscatter from spontaneous mammary tumors in rats are obtained over the frequency range of 4 to 12 MHz. The power spectra measured from rat tumors are compared to theoretical power spectra derived from a 3D spatial autocorrelation function assuming a Gaussian distribution. Independent values of average scatterer diameter and acoustic concentration are obtained by approximating the measured power spectrum with a best-fit line. Enhanced B-mode images are made of the rat tumors and surrounding tissues with superimposed regions of interest