Interleukin-17A in lipid metabolism and atherosclerosis英文文献资料.pdfVIP

Clinica Chimica Acta 431 (2014) 33–39 Contents lists available at ScienceDirect Clinica Chimica Acta journal homepage: www. else vi er. com/ locate /clinchim Invited critical review Interleukin-17A in lipid metabolism and atherosclerosis Xiao-Hua Yu a,1, Na Jiang b,1, Xi-Long Zheng c, Francisco S. Cayabyab d, Zhi-Bin Tang e,⁎, Chao-Ke Tang a,⁎⁎ a Life Science Research Center, Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China b Department of Electrocardiogram, the Second Affi liated Hospital, University of South China, Hengyang, Hunan 421001, China c Department of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta, The University of Calgary, Health Sciences Center, 3330 Hospital Dr NW, Calgary, Alberta, T2N 4N1, Canada d Department of Physiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada e Department of Orthopedics, the First Affi liated Hospital, University of South China, Hengyang, Hunan 421001, China a r t i c l e i n f o a b s t r a c t Article history: Interleukin-17 (IL-17) A, the most important cytokine of the IL-17 family predominantly secreted by T helper 17 Received 18 October 2013 (Th17) cells, plays a critical role in the development of inflammatory diseases. Its receptor is an obligate Received in revised form 7 January 2014 heterodimer composed of IL-17 receptor (IL-17R) A and C, the main members of the IL-17R family. Binding Accepted 9 January 2014