铜绿假单胞菌的群体感应系统及其抑制剂研究进展-中国抗生素杂志.PDFVIP

. 1338 . 中国抗生素杂志年月第卷第期 文章编号：-() -- 铜绿假单胞菌的群体感应系统及其抑制剂研究进展 1 2 2,* 高雅婷 李晓霞 段金菊 (天津市中医药研究院附属医院药剂科，天津； 山西医科大学第二医院药剂科，太原) 摘要：群体感应系统(quorum sensing system, QS) 是一种微生物细胞与细胞间的交流系统。铜绿假单胞菌是该系统的典型 代表，可调控细菌产生对抗生素的耐药、形成生物膜、产生毒力因子，并且减弱宿主的免疫应答。群体感应系统抑制剂(quorum sensing inhibitors, QSIs) 在不影响细菌生长的前提下可降低细菌的毒性，且增强细菌生物膜对抗生素治疗的敏感性，这些特点使 QSIs 成为目前抗感染领域的研发热点。本文就铜绿假单胞菌的群体感应系统及QSIs 的研究进展进行了综述。 关键词：群体感应系统；铜绿假单胞菌；群体感应抑制剂 中图分类号：Q 文献标志码：Ａ Study on quorum sensing system and its inhibitors of Pseudomonas aeruginosa 1 2 2 Gao Ya-ting , Li Xiao-xia and Duan Jin-ju (1 School of Pharmacy, Shanxi Medical University, Taiyuan 300120; 2 Department of Pharmacy, Second Hospital of Shanxi Medical University, Taiyuan 030013) Abstract Quorum sensing system (QS) is a communication system between microbial cells. Pseudomonas aeruginosa is a typical representative of this system, which regulates bacterial resistance to antibiotics, formation of biofilm, production of virulence factors and attenuating the host immune response. Without affecting bacterial growth, quorum sensing inhibitors (QSIs) could reduce bacterial toxicity and enhance the sensitivity of bacterial biofilm to antibiotic therapy. These characteristics making QSIs to be a research hot spot in the current anti-infective field. This review summarizes the current research advance on quorum sensing system and QSIs of Pseudomonas aeruginosa . Key words Quorum sensing system; Pseudomonas aeruginosa ; Quorum sensing inhibitors 群体感应系统(quorum sensing system, QS) 是一