病理学女性生殖系统和乳腺疾病.ppt

病理学女性生殖系统和乳腺疾病;子宫颈疾病;;;;;Normal cervix;Normal cervix;宫颈炎;;Nabothian cyst at 5 oclock;宫颈肿瘤;CIN I ：Mild dysplasia CIN II：Moderate dysplasia CIN III: Severe dysplasia and CIS;Cervical conization;;PAP smear;;; ????????????????????????????????????????????????????????? ;LSIL ;HSIL;Normal cervical squamous epithelium;CIN I;CIN I;CIN II;CIN III;CIN III;;;Carcinoma in situ (glands involved); It is important to emphasize that most (perhaps all) invasive cervical squamous cell carcinoma arise from precursor epithilial changes referred to as CIN. However, not all cases of CIN progress to invasive cancer, and indeed many persist without change or even regress.;CINI Regression 50-60% Persistence 30% Progression to CIN III 20% Progression to invasive cancer 1-5%;流行病学;The Death of Eva Peron Eva Peron (Evita), wife of Argentinas left-wing dictator Juan Peron, died in January 1952 of cervical cancer. ;宫颈癌;;;;;;Squamous cells carcinoma;Squamous cells carcinoma;Immunostaining for keratin ;Spreading ;;临床表现;宫颈癌分期 (FIGO,1985) 0 Preinvasive carcinoma Ⅰ Carcinoma strictly confined to the cervix Ⅱ Carcinoma that extends beyond the cervix, but does not extend into the pelvic wall Ⅲ Carcinoma that has extended into the pelvic sidewall Ⅳ Carcinoma that has extended beyond the true pelvis or has clinically involved the mucosa of the bladder and/or rectum ;五年生存率;滋养层细胞疾病 Gestational trophoblastic disease;;Implantation of the Placenta 5 days after fertilization ;6 days after fertilization;12 days after fertilization;a third-trimester placenta with baby;;葡萄胎 Hydatidiform mole;葡萄胎 Hydatidiform mole;Big uterus with mole;葡萄胎 Hydatidiform Mole;完全性葡萄胎 complete mole No associated baby The villi are uniformly swollen All the chromosomes from father (46XX,46XY) ;部分性葡萄胎 Partial mole May have a non-viable baby Unevenly swollen villi 69XXX, 69XXY;;;;Partial mole;临床表现;侵袭性葡萄胎 Invasive mole;绒毛膜癌 Choriocarcinoma ;患者，女，24岁，农民，孕3产1+2。 主诉：流产1年多，阴道不规则流血，痰中带血3月，头痛1月，呕吐3天。 现病史：1