药物线索比其他情感线索更敏感的电生理证据.pptVIP

Electrophysiological evidence that drug cues have greater salience than other affective stimuli in opiate addiction药物线索相比其他情感线索更敏感的电生理证据 摘要 Previous research has demonstrated that drug cues are able to capture attentional resources in addicted populations. However, few studies have controlled for the possibility that drug users find all motivationally significant (i.e., affective) stimuli particularly salient. We examined this issue in opiate addiction, by exploring the impact of drug-related and affective stimuli on central attentional processes. 以前的研究已经表明，在成瘾人群中药物线索更容易吸引他们注意。然而，很少有研究去控制毒品使用者去找到所有显著可能性的刺激(i.e., affective)、特别突出的动机。我们通过在阿片成瘾来探索药物相关的影响和在集中注意加工的情感刺激来调查这个问题 Sixteen male heroin addicts (seven on opiate pharmacotherapy and nine recently detoxified subjects) and 12 hed controls were studied. Subjects were fitted with a 32-channel electrode cap and were instructed to passively view a series of neutral, affective and opiate-related images. 6个男性海洛因成瘾者（7个是进行阿片药物治疗，9个是最近脱毒的被试）和12个匹配控制组进行研究。被试佩戴32通道的电极帽，被要求去看一系列中性、情感的和阿片相关的图片。 The P300 elicited by drug-related stimuli was significantly larger than that elicited by affective and neutral stimuli in opiate users but not controls. Baseline ratings of craving were also found tpredict the degree of P300 facilitation to the drug-related stimuli in the addicted group. Further, the opiate group demonstrated an absence of the typical enhancement of ERP responses to non-drug affective stimuli. 非控制的阿片使用者，药物相关刺激要比情感和中性刺激诱发的P300的波幅显著要大。在成瘾组中，对药物相关刺激渴求的基线等级被发现可以预测P300的程度。而且，在阿片使用组中显示出对于非药物情感刺激并没有典型ERP增强反应。 These results suggest that opiate addicts demonstrate greater cortical processing of drug cues than other types of affective stimuli. Further research is required to assess whether addiction is specifically associated with reduced sensitivity to natural rewards, aversive stimuli or affective cues in general. 这个结果表明阿片成瘾显示出，药物线索比其他类型的情感刺激有更大的皮层加工。进一步的研究应该要求去评估成瘾是否和对自然奖赏，厌恶刺激、或普通情感线索的敏感性减少之