PKPD在抗菌药物应用中指导作用.pptVIP

?vancomycin (AUC24/MIC400), at least 1 g q8h is needed to cover the infection caused by MRSAwith an MIC≤1 mg/L ?only the dose regimen of 1.5 g q6h provided a probability of target attainment higher than 90% if the MIC is 2 mg/L ?The same pattern was obtained when the fCmin/MIC ratio was considered ?PTA (AUC24/MIC100) higher than 90% for MICs≤2 mg/L ?For an MIC of 4 mg/L, the PTA reached a value of about 40% ?PTA values higher than 90% were only obtained with a dose regimen of 8 mg/kg or higher for MICs ≤1 mg/L; lower doses provided lower probabilities of target attainment AUC24/MIC666). ?For