临床医生如何正确规范应用抗生素.pptVIP

头孢哌酮联合舒巴坦 对61%的不动杆菌菌株表现出抗菌协同作用 对39%的不动杆菌菌株表现出抗菌相加作用 Jones RN, et al. Journal of Clinical Microbiology 1987; 25(9):1725-1729. *头孢哌酮/舒巴坦 0.5g/0.5g @头孢哌酮/舒巴坦 25mg/kg/25mg/kg 舒普深应对MDR非发酵菌机制之五：在多种组织、体液中分布良好 * * Pharmacokinetic (PK) and pharmacodynamic (PD) parameters are key to predicting the efficacy of antibiotics MIC values provide us with a static picture of how a pathogen is affected by fixed concentrations of antibiotic in vitro In the body, the antibiotic concentration is constantly changing – pharmacokinetic measurements can be used to estimate the dynamic situation