13十三真核基因表达的调控1.pptVIP

* * * * * * * * * * * * * * * * * * * * * * 迄今已发现的印迹基因已有150余个，大多成簇排列，其中许多是疾病基因。虽多数印迹基因的作用机制尚不清楚，然而几乎都与DNA甲基化型的异常相关联。 Cover LegendJust as the discovery of the Rosetta Stone in 1799 by Napoleons troops enabled Egytian hieroglyphics to be deciphered, mathematical bioinformatic techniques have allowed the imprint status of a gene to be predicted from cis-acting genomic motifs. This resulted in the genome-wide identification of genes in the human with high probability of being imprinted, and permitted the identification of candidate imprinted genes for complex human disorders where parent-of-origi