帕金森病早期诊断2016.ppt

PD早期诊断困难 下列六个特征“不支持” 帕金森病的诊断： （1）早期反复跌倒发作；（2）对L-DOPA治疗反应差；（3）症状对称发病；（4）病情迅速进展（3年达Hoehn and Yahr 3期）；（5）缺少震颤；（6）早期严重植物神经功能障碍（尿便失禁、尿储留需要导尿、持续勃起障碍、症状性体位性低血压）。 The following clinical features in early stages of disease should be considered to distinguish PD from other parkinsonian syndromes: 1) falls at presentation and early in the disease course, 2) poor response to levodopa, 3) symmetry at onset, 4) rapid progression (to Hoehn and Yahr stage 3 in 3 years), 5) lack of tremor, and 6) dysautonomia (urinary urgency/incontinence and fecal incontinence, urinary retention requiring catheterization,