珠黄霜对肛门术后创面愈合的临床试验观察.docVIP

优质好文档 优质好文档 珠黄霜对肛门术后创面愈合的临床试验观察 【关键词】肛门创面 P style=TEXT-INDENT: 24px【摘要】 目的 观察外用中药珠黄霜对肛门术后创面肉芽组织中羟脯氨酸（HYP）变化。方法 将50例低位单纯性肛瘘术后患者随机分为珠黄霜治疗组和马应龙麝香痔疮膏阳性药物对照组，分别在术后第3、7、14天创面肉芽组织上取材，应用碱水解比色法检测HYP的含量。结果 术后第7、14天创面HYP含量治疗组显著高于对照组，第3天二者差异无显著性。结论珠黄霜能显著提高肛门术后创面肉芽组织中HYP的含量。P style=TEXT-INDENT: 24px关键词 肛门创面 肉芽组织 羟脯氨酸 珠黄霜P style=TEXT-INDENT: 24px align=centerClinical and experimental study on treatmentP style=TEXT-INDENT: 24px align=centerwound with Zhuhuang FrostP style=TEXT-INDENT: 24px align=centerPan Renzhi，Ding Yijiang，Zheng Xueping.P style=TEXT-INDENT: 24px align=centerNanjing Municipal of T.C.M.Nanjing210001.P style=TEXT-INDENT: 24px【Abstract】 Objective To observe the effect of Zhuhuang Frost，（ZHF），an external preparation of Chinese herbal medicine.On level of hydroxy-proline（HYP）in surgical wound after and operation.Methods Fifty postoperˉationd patients after low position simple operation of anal fistula were randomly divided into two groups and treated with ZHF and Mayinglong Musk hemorrhoidal paste（MMHP）respectively.The level of HYP in granulation of woung was tested using alkaline hydrolysis assay at the3rd，7th and14th day after operation respectively.Results The HYP level tested at the7th and14th day after operation in the ZHF treated group was higher than that in the MMHP treated group，but those tested at the3rd postoperational day in the two groups was not different significantly.Conclusion ZHF could increase the HYP level in postoperational granulation of wound after anal operation.P style=TEXT-INDENT: 24pxKey words anal surgical granulation hydroxy-proline Zhuhuang FrostP style=TEXT-INDENT: 24px肛门部创面是临床较多见的开放伤口，愈合相对较迟缓，临床上一直缺乏客观的检测指标，而羟脯氨酸（HYP）作为被氧化的胶原成分，已是伤口愈合研究的通用指标，原中国中医药学会肛肠分会会长丁泽民老中医的经验方珠黄霜经多年临床运用，显示了良好的促愈效应，本文即选用珠黄霜及马应龙痔疮膏阳性药物外敷术后创面，观察愈合过程中肉芽组织内羟脯氨酸的变化，现将试验方法及结果报告如下。P style=TEXT-INDENT: 24px1 资料和方法P style=TEXT-INDENT: 24px1.1 一般资料 50例均为全国中医肛肠诊疗中心（南京市中医院）住院行低位单纯性肛瘘［低位单纯性肛瘘根据目前临床广泛采用的中国衡水会议肛瘘统一标准分类法案（1975年）诊断即痔管位于外括约肌深部下方且只有一个内、外口］切除术后的患者，按随机数字表法分为治疗组和对照组，其中