肥胖的并发症.pptVIP

0115010821 Ballantyne MD Medical Complications of Obesity BMI-Associated Disease Risk Body Mass Index Chart Relationship Between BMI and Percent Body Fat in Men and Women Medical Complications of Obesity Metabolic Syndrome Abdominal obesity Hyperinsulinemia High fasting plasma glucose Impaired glucose tolerance Hypertriglyceridemia Low HDL-cholesterol Hypertension Evolution of Metabolic Syndrome Characteristics of the Metabolic Syndrome: NCEP-ATP III Clinical Identification of the Metabolic Syndrome*: NCEP-ATP III Increasing Prevalence of NCEP Metabolic Syndrome with Age (NHANES III) Prevalence of CHD by the Metabolic Syndrome and Diabetes in the NHANES Population Age 50+ Prevalence of the Metabolic Syndrome Varies by Sex and Race/Ethnicity (NHANES III) Metabolic Syndrome: Impact on Mortality Metabolic Syndrome: Impact on Cardiovascular Health Elevated Risk of CVD Prior to Clinical Diagnosis of Type 2 Diabetes Characteristics of Metabolically Normal Obese and Metabolically Abnormal Obese Subjects? Lipids and Lipoproteins Resting BP in Insulin-Sensitive and Insulin-Resistant Obese Subjects? Oral Glucose Tolerance in Insulin-Sensitive and Insulin-Resistant Obese Subjects? Waist Size vs BMI and the Metabolic Syndrome Both Insulin Resistance and Decreased Insulin Secretion Predict the Risk of Developing Type 2 Diabetes: 7-Year Incidence Distribution by Metabolic Status Among Converters to Type 2 Diabetes(83% of Prediabetic Subjects are Insulin Resistant) Insulin Resistance (HOMA-IR Quintiles) are Related to CV Disease: San Antonio Heart Study Intra-Abdominal Fat Mass and CHD Risk in Type 2 Diabetes Ectopic Lipids and the Metabolic Syndrome Metabolic syndrome reflects failure of intracellular lipohomeostasis, which prevents lipotoxicity in organs of overnourished individuals Normal individuals: lipohomeostasis (ie, lipid overload confined to white adipocytes, designed to store surplus calories) Obese individuals: adipocytes increase leptin secretion in an attempt to e