医学免疫学06－细胞因子.pptVIP

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Effector and regulatory CD4+ T cell subsets involved in achieving the balance between the anti-infective immune response and host pathology. Th17 and Treg Cells Th17 (CD4+, FoxP3-) IL-17 is a pro-inflammatory cytokine Promotes secretion of pro-inflammatory cytokines (IL-6) from fibroblasts, epithelial and endothelial cells. Th17 cells are critical to anti-bacterial immunity. Overexpression of IL-17 is associated with rheumatoid arthritis, SLE, MS and asthma Treg (CD4+, Foxp3+) Natural (develop in